This research is among the first to examine the partnership out-of lean body mass so you can vasomotor periods longitudinally

19 Feb 2024

This research is among the first to examine the partnership out-of lean body mass so you can vasomotor periods longitudinally

Characteristics of the sample were described by means (standard deviation) and frequency (%). At baseline, two VMS groups – any or none – were compared for group differences in, and associations among, demographics (age, race/ethnicity, education), quality of life (SF-36 score), and clinical characteristics (weight, hip and waist circumference, menopausal korealainen seksikkГ¤itГ¤ naisia status, fat mass, fat free mass, skeletal mass), and VMS was estimated using chi square test (x 2 ) for categorical variables, and Kruskal-Wallis test for continuous variables. A scatter plot matrix was used to examine linear correlations among variables. For the purposes of modelling, LBM is represented by the SMI variable. Additionally, to account for the nonindependence of longitudinal observations derived from the same woman and data in which the number of observations may differ across women, longitudinal modeling using SAS PROC MIXED incorporated a random intercept term to account for the correlated errors among repeated measures of the same woman. Missing values of time-varying variables were interpolated based on prior and subsequent values for gaps of one to two visits as in previous SWAN analyses . To assess Hstep one, incident VMS was modeled as a function of concurrent LBM using logistic regression analysis. To address H2 regarding long term change in LBM, the model was expanded to add within-woman percent change in LBM since baseline and to address H3, regarding recent change in LBM, the model was expanded to add within-woman percent change in LBM since prior visit (approximately 1 year earlier). The overall association between LBM and VMS was estimated in binary logistic regression models. Statistical analyses were one-tailed with an alpha level of 0.05 and conducted using SAS University Edition (© 2012–2018, SAS Institute Inc., Cary, NC).


From the standard (go to 6) there were 2533 professionals staying in the latest SWAN analysis who had been an average of 52 yrs old plus the differences in the team services are provided for the Desk step one. Simply women revealing no attacks at baseline (letter = 1179) have been used in longitudinal analyses getting VMS that have LBM. From the go to 10 there had been 800 feminine staying in the analysis.

At baseline, SMI showed a strong positive correlation to FFMI both for symptoms = none (r0 (864) = 0.931, p Table 2 Association of VMS to lean body mass (Odds Ratios)

Forecast probability of episodes occurring during the given degrees of SMI (modified to own FFMI and you may FMI) in females without VMS at the visit six (baseline)


By using the study for it highest, multiethnic test out-of mid-years feminine about SWAN studies, i learned that members that have highest relative degrees of LBM was less likely to produce VMS while they transitioned thanks to menopause. Which impression are found to be separate out of sociodemographic circumstances and you can quantities of lbs mass. In addition, because the mediocre period of the players within research enhanced off 52.0 to 56.6 age together with level of women that had been postmenopausal increased off forty% (n = 430) within see 6 to 72% (n = 733) in the visit ten, the research was able to file new path through menopausal changeover for some the newest cohort.

Significant previous studies have concerned about the association from muscles size index (BMI) and percent body fat having VMS and also suggested a positive correlation ranging from expanding Body mass index plus the exposure away from VMS [29, thirty-two,33,34,thirty five,36]. But not, Bmi is a terrible predictor away from body bulk whilst simply a way of measuring excess weight and will not differentiate anywhere between extra fat bulk and you can fat free bulk . Our study checked out the ingredients of muscles structure and found lean bulk, determined by one another fat-free mass and you can skeletal muscle, for a life threatening impact on the possibilities of development VMS over the years when you are nevertheless considering the potential perception off weight bulk. A recently available get across-sectional study of 758 women learned that trunk area lean mass is actually a separate defensive basis to have average in order to significant menopause episodes and you can that VMS were separately associated with highest Bmi and fat mass . The root systems of relationship ranging from human anatomy structure and you may VMS aren’t completely clear due to the incomplete understanding of this new structure from VMS .